As human lifespan is enhanced by modern medicine, late-onset neurodegenerative disorders such as Alzheimer’s, Parkinson’s and Huntington’s diseases are becoming an increasing burden, affecting millions of people worldwide.

The YLS2012 Therapeutics symposium will be focus on the process of translating basic research into novel therapies, which draws researchers from physiology, biochemistry, pharmacology and genetics together with clinicians and industrial partners.

See our programme below – you can also now download the delegate booklet here.

8:00-09:00 Delegates arrive, refreshments, time to put posters up
09:00-09:15 Introduction to the day
SESSION 1: In Vitro, Cell and Fly models of Neurodegenerative Disease
09:15-09:35 Shmma Quraishe: NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy
09:35-09:55 Billy West: The role of lipids in prion propagation
09:55-10:15 Tania Papkovskaia: G2019S LRRK2 causes uncoupling protein mediated mitochondrial depolarisation
10:15-11:00 Key note talk – Dr. Flav Giorgini – Drug discovery in Huntington’s Disease: novel mechanisms and drug targets
11:00-11:30 Coffee Break
SESSION 2: Behavioural Neuroscience and Animal Models
11:30-11:50 John Anderson: Effects of Rosiglitazone on spatial cognition in adult male Tg2576 mice
11:50-12:10 Ross Mounsey: The endocannabinoid 2-AG provides neuroprotection in the MPTP model of Parkinson’s disease
12:10-12:30 Matthew Davies: Neurodegeneration associated stress responses in an in vivo model of extracellular protein misfolding disease
12:30-13:45 Key note talk – Professor Lesley Jones  – Parallels between human Huntington’s disease and genetically manipulated mouse models of disease
13:45-15:30 Lunch and poster viewing
15:30-16:00 Patient perspectives with Matty Ellison from Huntington’s Disease Youth Organisation and Jenni McCabe from PDUK.
16:00-16:30 Coffee Break
SESSION 3: Human Genetics, Clinical Research and Therapeutics
16:30-16:50 Elizabeth Hartfield: Utilising patient-derived iPS cells to study cellular dysfunction in Parkinson’s disease
16:50-17:10 Faye Begeti: Hippocampal function in Huntington’s disease: translating animal findings to clinical practice
17:10-17:30 Ralph Andre: Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression
17:30-18:15 Key note talk – Professor Anthony Schapira – Understanding aetiology as a basis for treatment in Parkinson’s disease
Evening Poster and Talk prizes, wine and cheese reception