As human lifespan is enhanced by modern medicine, late-onset neurodegenerative disorders such as Alzheimer’s, Parkinson’s and Huntington’s diseases are becoming an increasing burden, affecting millions of people worldwide.
The YLS2012 Therapeutics symposium will be focus on the process of translating basic research into novel therapies, which draws researchers from physiology, biochemistry, pharmacology and genetics together with clinicians and industrial partners.
See our programme below – you can also now download the delegate booklet here.
|8:00-09:00||Delegates arrive, refreshments, time to put posters up|
|09:00-09:15||Introduction to the day|
|SESSION 1: In Vitro, Cell and Fly models of Neurodegenerative Disease|
|09:15-09:35||Shmma Quraishe: NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy|
|09:35-09:55||Billy West: The role of lipids in prion propagation|
|09:55-10:15||Tania Papkovskaia: G2019S LRRK2 causes uncoupling protein mediated mitochondrial depolarisation|
|10:15-11:00||Key note talk – Dr. Flav Giorgini – Drug discovery in Huntington’s Disease: novel mechanisms and drug targets|
|SESSION 2: Behavioural Neuroscience and Animal Models|
|11:30-11:50||John Anderson: Effects of Rosiglitazone on spatial cognition in adult male Tg2576 mice|
|11:50-12:10||Ross Mounsey: The endocannabinoid 2-AG provides neuroprotection in the MPTP model of Parkinson’s disease|
|12:10-12:30||Matthew Davies: Neurodegeneration associated stress responses in an in vivo model of extracellular protein misfolding disease|
|12:30-13:45||Key note talk – Professor Lesley Jones – Parallels between human Huntington’s disease and genetically manipulated mouse models of disease|
|13:45-15:30||Lunch and poster viewing|
|15:30-16:00||Patient perspectives with Matty Ellison from Huntington’s Disease Youth Organisation and Jenni McCabe from PDUK.|
|SESSION 3: Human Genetics, Clinical Research and Therapeutics|
|16:30-16:50||Elizabeth Hartfield: Utilising patient-derived iPS cells to study cellular dysfunction in Parkinson’s disease|
|16:50-17:10||Faye Begeti: Hippocampal function in Huntington’s disease: translating animal findings to clinical practice|
|17:10-17:30||Ralph Andre: Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression|
|17:30-18:15||Key note talk – Professor Anthony Schapira – Understanding aetiology as a basis for treatment in Parkinson’s disease|
|Evening||Poster and Talk prizes, wine and cheese reception|